Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1997

Zhang H, Peterson J W, Niesel D W, Klimpel G R

Abstract excerpt

Septic shock is a major cause of death in the world. Although much is known about the role of LPS in septic shock, little is known about the role of other bacterial components. Lipoprotein (LP) is a major component of bacteria in the family Enterobacteriaceae. LP purified from Escherichia coli was shown to induce TNF-alpha and IL-6 production in peritoneal exudate macrophages obtained from LPS-responsive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli
Share to TNF gene
Share to Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins

Share to Mice, Inbred C3H

Share to Mutation

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 9366412

Genes

TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production.PMID 9366412Read ↗

Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice.Semantic proximity Read ↗

Lipoprotein Release by Bacteria: Potential Factor in Bacterial PathogenesisSemantic proximity Read ↗

Non-lipooligosaccharide-mediated signalling via Toll-like receptor 4 causes fatal meningococcal sepsis in a mouse model.Semantic proximity Read ↗

Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During SepsisSemantic proximity Read ↗

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock.Semantic proximity Read ↗

Peptidoglycan and Lipoteichoic Acid in Gram-Positive Bacterial Sepsis: Receptors, Signal Transduction, Biological Effects, and SynergismSemantic proximity Read ↗

Novel Regulators of the Systemic Response to LipopolysaccharideSemantic proximity Read ↗

Bacterial Peptidoglycan‐Associated Lipoprotein: A Naturally Occurring Toll‐Like Receptor 2 Agonist That Is Shed into Serum and Has Synergy with LipopolysaccharideSemantic proximity Read ↗

Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis.Semantic proximity Read ↗

The essential role of lipopolysaccharide-binding protein in protection of mice against a peritoneal Salmonella infection involves the rapid induction of an inflammatory response.Semantic proximity Read ↗

Apolipoprotein E‐deficient mice have an impaired immune response to <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.