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Article

Activated macrophages induce hepcidin expression in HuH7 hepatoma cells.

Haematologica - 1 Jun 2009

Matak Pavle, Chaston Timothy B, Chung Bomee, Srai Surjit Kaila, McKie Andrew T, Sharp Paul A

Abstract excerpt

BACKGROUND: Hepcidin is an iron regulatory peptide produced by the liver in response to inflammation and elevated systemic iron. Recent studies suggest that circulating monocytes and resident liver macrophages--Küpffer cells--may influence both basal and inflammatory expression of hepcidin. DESIGN AND METHODS: We used an in vitro co-culture model to investigate hepatocyte hepcidin regulation in the presence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19454498
DOI: 10.3324/haematol.2008.003400
PMCID: PMC2688568

Genes

HAMP
EBP
SMAD4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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