Article
Convergence of cell cycle regulation and growth factor signals on GRASP65.
The Journal of biological chemistry - 17 Jun 2005
Yoshimura Shin-ichiro, Yoshioka Katsuji, Barr Francis A, Lowe Martin, Nakayama Kazuhisa, Ohkuma Shoji, Nakamura Nobuhiro
Abstract excerpt
Together with other Golgi matrix components, GRASP65 contributes to the stacking of Golgi cisternae in interphase cells. During mitosis, GRASP65 is heavily phosphorylated, and in turn, cisternal stacking is inhibited leading to the breakdown of the Golgi apparatus. Here we show that GRASP65 is phosphorylated on serine 277 in interphase cells, and this is strongly enhanced in response to the addition of serum or...
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