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Article

Phosphorylation of Cdc6 at serine 74, but not at serine 106, drives translocation of Cdc6 to the cytoplasm.

Journal of cellular physiology - 1 Jun 2013

Yim Hyungshin, Park Ji-Woong, Woo Sang Uk, Kim Seong-Taek, Liu Linhua, Lee Chul-Hoon, Lee Seung Ki

Abstract excerpt

Phosphorylation-dependent cytoplasmic translocation of human Cdc6 during S phase is sufficient to control its activity after origin firing. Export from the nucleus also serves as a mechanism for preventing re-replication in mammalian cells. Phosphorylation of the CDK consensus serine residues 54, 74, and 106 has been suggested to be involved in the cytoplasmic translocation of Cdc6. To determine the relative...

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PMID: 23129444
DOI: 10.1002/jcp.24275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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