Article
Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2006
Gioeli Daniel, Black Ben E, Gordon Vicki, Spencer Adam, Kesler Cristina T, Eblen Scott T, Paschal Bryce M, Weber Michael J
Abstract excerpt
Activation of signal transduction kinase cascades is known to alter androgen receptor (AR) activity, but the molecular mechanisms are still poorly defined. Here we show that stress kinase signaling regulates Ser 650 phosphorylation and AR nuclear export. In LNCaP prostate cancer cells, activation of either MAPK kinase (MKK) 4:c-Jun N-terminal kinase (JNK) or MKK6:p38 signaling pathways increased Ser 650...
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