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Article

An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head.

Science (New York, N.Y.) - 15 Apr 2005

Mace Kimberly A, Pearson Joseph C, McGinnis William

Abstract excerpt

We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells...

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Source

Identifiers

PMID: 15831751
DOI: 10.1126/science.1107573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head.PMID 15831751Read ↗

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The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers.Semantic proximity Read ↗

Grainyhead genes and mammalian neural tube closure.Semantic proximity Read ↗

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.Semantic proximity Read ↗

The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes.Semantic proximity Read ↗

Multiple transcription factor codes activate epidermal wound-response genes in Drosophila.Semantic proximity Read ↗

The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing.Semantic proximity Read ↗

JNK signaling pathway is required for efficient wound healing in Drosophila.Semantic proximity Read ↗

The dorsal-open group gene raw is required for restricted DJNK signaling during closure.Semantic proximity Read ↗

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