Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization

7 Sept 2021

Abstract excerpt

The migrating keratinocyte wound front is required for skin wound closure. Despite significant advances in wound healing research, we do not fully understand the molecular mechanisms that orchestrate collective keratinocyte migration. Here, we show that, in the wound front, the epidermal transcription factor Grainyhead like-3 (GRHL3) mediates decreased expression of the adherens junction protein E-cadherin; this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Mechanics and Interactions
Share to Polysaccharides and Plant Cell Walls
Share to Wound Healing and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34494554
DOI: 10.1172/jci.insight.142577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelializationPMID 34494554Read ↗

Spatiotemporal Single-Cell Roadmap of Human Skin Wound HealingSemantic proximity Read ↗

Spatiotemporal single-cell roadmap of human skin wound healingSemantic proximity Read ↗

4D multimodal wound healing atlas reveals organ-level controls of repair phase transitionsSemantic proximity Read ↗

FAM83H couples keratin organization to Notch signaling during epidermal morphogenesisSemantic proximity Read ↗

Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell statesSemantic proximity Read ↗

The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.Semantic proximity Read ↗

Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migrationSemantic proximity Read ↗

The Fraser complex interconnects tissue layers to support basal epidermis and osteoblast integrated morphogenesis underlying fin skeletal patterningSemantic proximity Read ↗

StrataChip: a microphysiological system capturing dynamic keratinocyte fate and mechanical transitions during human epidermal morphogenesisSemantic proximity Read ↗

Integrated spatial multiomics reveals fibroblast fate during tissue repairSemantic proximity Read ↗

The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healingSemantic proximity Read ↗

Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.