Article
Treatment Response and GWAS Risk Allele rs2514218 (C) of the Dopamine D2 Receptor Gene in Inpatients with Schizophrenia.
Neuropsychobiology - 1 Jan 2022
Morozova Margarita A, Lezheiko Tatyana V, Lepilkina Taissia A, Burminskiy Denis S, Potanin Sergey S, Beniashvili Allan G, Rupchev George E, Golimbet Vera E
Abstract excerpt
INTRODUCTION: The pathophysiological mechanisms of acute schizophrenia are largely unknown, but it is widely accepted that dopamine D2 receptors (DRD2s) are involved in psychosis treatments for schizophrenic patients. We suggest that genetic variation in these receptors may play a role in patients' responses to commonly used antipsychotics, particularly D2-blockers. METHODS: This study included adult patients...
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