Article
Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2006
Hwang Rudi, Shinkai Takahiro, Deluca Vincenzo, Macciardi Fabio, Potkin Steven, Meltzer Herbert Y, Kennedy James L
Abstract excerpt
OBJECTIVE: Explore relationships between 12 dopamine D2 gene variants and quantitative measures of positive and negative symptom response following clozapine treatment in two treatment refractory or intolerant populations (Caucasian and African-American). EXPERIMENTAL PROCEDURES: Subjects included 97 Caucasian and 35 African-American DSM-III-R or DSM-IV schizophrenics and were genotyped by 5'-exonuclease...
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