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Article

AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Apr 2005

Robert Antoine, Armstrong Neali, Gouaux J Eric, Howe James R

Abstract excerpt

Glutamate binds to AMPA receptors within a deep cleft between two globular protein domains (domains 1 and 2). Once glutamate binds, the cleft closes, and agonist-bound structures of the isolated ligand binding core suggest that closure of the binding cleft is sufficiently complete that it essentially prevents ligand dissociation. There is also considerable evidence supporting the view that cleft closure is the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15829627
DOI: 10.1523/JNEUROSCI.0188-05.2005
PMCID: PMC6724928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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