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Article

Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jan 2008

Zhang Wei, Cho Yoonsang, Lolis Elias, Howe James R

Abstract excerpt

At most excitatory central synapses, glutamate is released from presynaptic terminals and binds to postsynaptic AMPA receptors, initiating a series of conformational changes that result in ion channel opening. Efficient transmission at these synapses requires that glutamate binding to AMPA receptors results in rapid and near-synchronous opening of postsynaptic receptor channels. In addition, if the information...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18216201
DOI: 10.1523/JNEUROSCI.3309-07.2008
PMCID: PMC6670991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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