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Article

The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.

The Journal of biological chemistry - 10 Aug 2001

Langland G, Kordich J, Creaney J, Goss K H, Lillard-Wetherell K, Bebenek K, Kunkel T A, Groden J

Abstract excerpt

Bloom's syndrome (BS) is a rare autosomal recessive disorder characterized by pre- and postnatal growth deficiency, immunodeficiency, and a tremendous predisposition to a wide variety of cancers. Cells from BS individuals are characterized by a high incidence of chromosomal gaps and breaks, eleva...

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Source

Identifiers

PMID: 11325959
DOI: 10.1074/jbc.M009664200

Genes

BLM
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11325959-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.PMID 11325959Read ↗

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

The Bloom's Syndrome Helicase Interacts Directly with the Human DNA Mismatch Repair Protein hMSH6Semantic proximity Read ↗

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Semantic proximity Read ↗

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.Semantic proximity Read ↗

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.Semantic proximity Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.Semantic proximity Read ↗

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