Article
Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.
Human molecular genetics - 1 Jun 2001
Hu P, Beresten S F, van Brabant A J, Ye T Z, Pandolfi P P, Johnson F B, Guarente L, Ellis N A
Abstract excerpt
The genomic instability of persons with Bloom's syndrome (BS) features particularly an increased number of sister-chromatid exchanges (SCEs). The primary cause of the genomic instability is mutation at BLM, which encodes a DNA helicase of the RecQ family. BLM interacts with Topoisomerase IIIalpha (Topo IIIalpha), and both BLM and Topo IIIalpha localize to the nuclear organelles referred to as the promyelocytic...
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