Article
The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability.
BMC cell biology - 1 Jan 2001
Yankiwski V, Noonan J P, Neff N F
Abstract excerpt
BACKGROUND: Bloom syndrome is a rare cancer-prone disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. Bloom syndrome cells have a distinctive high frequency of sister chromatid exchange and quadriradial formation. BLM, the protein altered in BS, is a member of the RecQ DNA helicase family, whose members share an average of 40% identity in the helicase...
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