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Article

Hemifusion in SNARE-mediated membrane fusion.

Nature structural & molecular biology - 1 May 2005

Xu Yibin, Zhang Fan, Su Zengliu, McNew James A, Shin Yeon-Kyun

Abstract excerpt

SNAREs are essential for intracellular membrane fusion. Using EPR, we determined the structure of the transmembrane domain (TMD) of the vesicle (v)-SNARE Snc2p involved in trafficking in yeast. Structural features of the TMD were used to design a v-SNARE mutant in which about half of the TMD was deleted. Liposomes containing this mutant induced outer leaflet mixing but not inner leaflet mixing when incubated with...

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Identifiers

PMID: 15821745
DOI: 10.1038/nsmb921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Double-Transmembrane Domain of SNAREs Decelerates the Fusion by Increasing the Protein-Lipid Mismatch.Semantic proximity Read ↗

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Hemagglutinin fusion peptide mutants in model membranes: structural properties, membrane physical properties, and PEG-mediated fusion.Semantic proximity Read ↗

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