Article
The lipid composition and physical properties of the yeast vacuole affect the hemifusion-fusion transition.
Traffic (Copenhagen, Denmark) - 1 Jun 2013
Karunakaran Surya, Fratti Rutilio A
Abstract excerpt
Yeast vacuole fusion requires the formation of SNARE bundles between membranes. Although the function of vacuolar SNAREs is controlled in part by regulatory lipids, the exact role of the membrane in regulating fusion remains unclear. Because SNAREs are membrane-anchored and transmit the force required for fusion to the bilayer, we hypothesized that the lipid composition and curvature of the membrane aid in...
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