Article
Porphyrin photosensitization of multi-drug resistant cell types.
Photochemistry and photobiology - 1 Mar 1992
Kessel D, Erickson C
Abstract excerpt
The P388 murine leukemia and P388/ADR, a subline expressing the multi-drug resistance (MDR) phenotype, were examined with regard to the role of MDR as a determinant of responsiveness to photodynamic therapy in vitro. Mesoporphyrin was used as a model substrate. We found no differences in porphyrin accumulation nor transport alterations associated with exposure of P388/ADR cells to the verapamil analog DMDP. There...
Topics
- Animals
- Antibiotics, Antineoplastic
- Drug Resistance
- Mesoporphyrins
- Phenotype
- Photochemotherapy
- Radiation-Sensitizing Agents
- Tumor Cells, Cultured