Article
Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro.
Investigational new drugs - 1 Jan 1998
Etievant C, Barret J M, Kruczynski A, Perrin D, Hill B T
Abstract excerpt
Vinflunine (VFL) is a novel derivative of vinorelbine (NVB, Navelbine), which has shown markedly superior antitumor activity to NVB, in various experimental animal models. To establish whether this new Vinca alkaloid participates in P-glycoprotein (Pgp)-mediated multidrug resistance (MDR), VFL-re...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents, Phytogenic
- Calcium Channel Blockers
- Doxorubicin
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Female
- Humans
- Leukemia P388
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Phenotype
- Tumor Cells, Cultured
- Verapamil
- Vinblastine