Article
Relating multidrug resistance phenotypes to the kinetic properties of their drug-efflux pumps.
European journal of biochemistry - 1 Sept 2000
Westerhoff H V, Riethorst A, Jongsma A P
Abstract excerpt
The simplest model for pump-mediated multidrug resistance is elaborated quantitatively. The way in which toxicity data should be evaluated to characterize most effectively the drug-efflux pump is then examined. The isotoxic drug dose (D10) depends on too many unrelated properties. The D10 of a cell line taken relative to that of the parental (nonresistant) cell line has been called the relative resistance (RR)....
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