Flow cytometric evaluation of multidrug-resistance circumvention.

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Article

Flow cytometric evaluation of multidrug-resistance circumvention.

Bulletin du cancer - 1 Jan 1995

Léonce S, Pierré A, Atassi G

Abstract excerpt

Flow cytometry, through the measurement of P-gp expression and function, is an important tool in the characterization of multidrug resistant cell lines used in pharmacology. Furthermore, as a complement to classical in vitro tests, this technique allows rapid evaluation of the capacity of new modulator agents to reverse the resistance to cytotoxic drugs and contributes a deeper insight into the mechanism of...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Cell Cycle
Doxorubicin
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Flow Cytometry
Humans
Neoplasm Proteins
Phenotype
Tumor Cells, Cultured

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Open in PubMed

Identifiers

PMID: 10846527

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