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Article

In vitro mutational specificity of cisplatin in the human hypoxanthine guanine phosphoribosyltransferase gene.

Cancer research - 15 May 1992

Cariello N F, Swenberg J A, Skopek T R

Abstract excerpt

The in vitro mutational spectra of cisplatin [cis-diamminedichloroplatinum(II)] in exon 3 of the human hypoxanthine guanine phosphoribosyltransferase gene in B-lymphoblasts was examined by a combination of polymerase chain reaction and denaturing gradient gel electrophoresis. Several thousand independent mutants were induced at the hypoxanthine guanine phosphoribosyltransferase locus by cisplatin and were...

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PMID: 1581901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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