Article
Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity.
Carcinogenesis - 1 Aug 1994
Wei S J, Chang R L, Hennig E, Cui X X, Merkler K A, Wong C Q, Yagi H, Jerina D M, Conney A H
Abstract excerpt
Earlier studies from our laboratories characterized the mutation profile of the optically active (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-BPDE--the ultimate carcinogenic metabolite of benzo[a]pyrene] in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells. In the present study, we evaluated the mutation profile of...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Animals
- Base Sequence
- Cells, Cultured
- Cricetinae
- Cricetulus
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation
- Stereoisomerism