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Article

A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2007

Mishra Prasun J, Humeniuk Rita, Mishra Pravin J, Longo-Sorbello Giuseppe S A, Banerjee Debabrata, Bertino Joseph R

Abstract excerpt

MicroRNAs are predicted to regulate approximately 30% of all human genes by targeting sequences in their 3' UTR. Polymorphisms in 3' UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C-->T, a naturally occurring SNP, near the miR-24 binding site in the 3' UTR of human dihydrofolate reductase (DHFR) affects DHFR expression by...

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Identifiers

PMID: 17686970
DOI: 10.1073/pnas.0706217104
PMCID: PMC1948927

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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