Article
Persistence of K-ras mutations in plasma after colorectal tumor resection.
Anticancer research - 1 Jan 2000
Lindforss Ulrik, Zetterquist Henrik, Papadogiannakis Nikos, Olivecrona Hans
Abstract excerpt
Free DNA in the circulation is increased five-to ten-fold in patients with solid tumours compared to healthy controls. A range of tumor-specific mutated DNA has been shown to be readily extractable and possible to analyse from plasma and serum in these patients. K-ras oncogene mutations are an early event in a subset of colorectal tumors and have been found in 30-60% of patients with colorectal carcinoma (CRC)....
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