Article
Detection of mutant k-ras sequences in the urine of cancer patients.
Bulletin of experimental biology and medicine - 1 Mar 2001
Serdyuk O I, Botezatu I V, Shelepov V P, Potapova G I, Alekhina R P, Molyaka Y K, Anan'ev V S, Knysh V I, Melkonyan O S, Umanskii S R, Lichtenshtein A V
Abstract excerpt
DNA fragments from apoptotic cells crossing the renal barrier retain their matrix functions, which allows PCR identification of mutant sequences in excreted DNA. We investigated the possibility of detecting k-ras mutations in urinary DNA of tumor patients (colon cancer). In some patients with k-ras codon 12 mutations in tumor cell DNA the same changes were detected in the urinary DNA. The possibility of using...
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