Article
K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
Archives of surgery (Chicago, Ill. : 1960) - 1 Jan 1995
Kastrinakis W V, Ramchurren N, Maggard M, Steele G, Summerhayes I C
Abstract excerpt
OBJECTIVE: To establish whether specific K-ras alterations are predictive of less aggressive tumor behavior and subsequently those patients who are most likely to benefit from resection of hepatic metastases from colorectal carcinoma. DESIGN: Evaluation of long-term survivors of hepatic resection for metastases of colorectal carcinoma (median survival, 85 months). RESULTS: DNA, extracted from 26 paraffin-embedded...
Topics
- Adenocarcinoma
- Base Sequence
- Codon
- Colorectal Neoplasms
- DNA, Neoplasm
- Exons
- Genes, ras
- Humans
- Liver Neoplasms
- Molecular Sequence Data
- Mutation