Stability of K-ras mutations throughout the natural history of human colorectal cancer.

doi:10.1016/0959-8049(92)90468-h

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Article

Stability of K-ras mutations throughout the natural history of human colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1992

Losi L, Benhattar J, Costa J

Abstract excerpt

We have used a rapid, non-radioactive and sensitive method based on allele-specific amplification using the polymerase chain reaction for the identification of K-ras mutations in archival tissues of colorectal carcinomas. Our purpose was to determine whether or not K-ras mutation provides, when p...

Topics

Adenocarcinoma
Aged
Aged, 80 and over
Base Sequence
Biomarkers, Tumor
Colorectal Neoplasms
DNA, Neoplasm
Female
Genes, ras
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Neoplasm Recurrence, Local
Polymerase Chain Reaction

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