Article
Interleukin-6, interleukin-1 gene cluster and interleukin-1 receptor polymorphisms in Iranian patients with juvenile systemic lupus erythematosus.
European cytokine network - 1 Jun 2014
Ziaee Vahid, Tahghighi Fatemeh, Moradinejad Mohammad Hassan, Harsini Sara, Mahmoudi Maryam, Rezaei Arezou, Soltani Samaneh, Sadr Maryam, Aghighi Yahya, Rezaei Nima
Abstract excerpt
BACKGROUND: Juvenile systemic lupus erythematosus (JSLE) is a polygenic, autoimmune disorder of unknown origin. As proinflammatory cytokines, including interleukin-6 (IL-6) and the interleukin-1 (IL-1) family, seem to contribute to the pathogenesis of JSLE, this investigation was performed to assess the associations of particular single nucleotide polymorphisms (SNPs) of IL-6 and IL-1 genes in a case-control...
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