Article
Mitochondrial DNA mutations in oral squamous cell carcinoma.
Carcinogenesis - 1 May 2006
Prior S L, Griffiths A P, Baxter J M, Baxter P W, Hodder S C, Silvester K C, Lewis P D
Abstract excerpt
It has previously been demonstrated that mitochondrial DNA (mtDNA) mutations within the ND2 gene of histologically normal parotid salivary gland tissue of smokers may be molecular biomarkers for smoking-induced mtDNA damage. Oral squamous cell carcinoma (SCC) is strongly related to cigarette smoking; therefore, we used PCR and direct sequencing to establish whether mtDNA mutations were also present in oral SCC...
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