Article
DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability.
Scandinavian journal of infectious diseases - 1 Jan 2001
Boshoff H I, Durbach S I, Mizrahi V
Abstract excerpt
In this paper, we review the evidence supporting the notion that the genome of Mycobacterium tuberculosis sustains considerable damage as a result of exposure to nitrosative and oxidative stress. On these grounds, we propose a model in which stress-induced DNA damage in M. tuberculosis plays a role in the evolution of chromosomally encoded drug resistance mutations by altering the global mutation rate by...
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