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Article

An amino-terminal motif functions as a second nuclear export sequence in BRCA1.

The Journal of biological chemistry - 10 Jun 2005

Thompson Marilyn E, Robinson-Benion Cheryl L, Holt Jeffrey T

Abstract excerpt

Mutations in the breast cancer susceptibility gene 1 (BRCA1) account for a substantial percentage of familial breast and ovarian cancers. Although BRCA1 is thought to function within the nucleus, it has also been located in the cytoplasm. In addition, BRCA1 accumulates in the nucleus of cells treated with leptomycin B, an inhibitor of chromosome region maintenance 1-mediated nuclear export, indicative of its...

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Source

Identifiers

PMID: 15811849
DOI: 10.1074/jbc.M502676200

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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