Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a nuclear export sequence in the MHC CIITA.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Chiu Emily, Gold Theresa, Fettig Veronica, LeVasseur Michael T, Cressman Drew E

Abstract excerpt

Initiation of an immune response through expression of MHC class II and related genes is under the control of the CIITA. Normally found in both the cytoplasm and nucleus, CIITA is tightly controlled by a variety of posttranslational modifications as well as interactions with other nuclear and cytoplasmic factors, whereas disruption of this dual subcellular localization impairs CIITA functioning and expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consensus Sequence

Share to COS Cells

Share to Exportin 1 Protein

Share to Interferon-gamma

Share to Karyopherins

Share to Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 25948812
DOI: 10.4049/jimmunol.1402026

Genes

CIITA
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a nuclear export sequence in the MHC CIITA.PMID 25948812Read ↗

CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.Semantic proximity Read ↗

Importance of class II transactivator leucine-rich repeats for dominant-negative function and nucleo-cytoplasmic transport.Semantic proximity Read ↗

The AIR-1 encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and .. more.Semantic proximity Read ↗

Importins and exportins regulating allergic immune responses.Semantic proximity Read ↗

The mechanisms regulating the subcellular localization of AID.Semantic proximity Read ↗

IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity.Semantic proximity Read ↗

Identification of multiple nuclear export sequences in Fanconi anemia group A protein that contribute to CRM1-dependent nuclear export.Semantic proximity Read ↗

A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.Semantic proximity Read ↗

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X ComplexSemantic proximity Read ↗

New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.Semantic proximity Read ↗

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.Semantic proximity Read ↗

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.