Article
Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function.
Cancer research - 15 Apr 2001
Liang X H, Yu J, Brown K, Levine B
Abstract excerpt
Beclin 1 encodes a Bcl-2-interacting coiled-coil protein with autophagy and tumor suppressor function and is monoallelically deleted in 40-75% of sporadic human breast and ovarian cancers. Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport. In this study, we show...
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