Article
The role of the AUUUUA hexamer for the posttranscriptional regulation of the AT1 receptor mRNA stability.
Biochemical and biophysical research communications - 13 May 2005
Berger Anja, Stierkorb Eva, Nickenig Georg
Abstract excerpt
AT1 receptor expression is mainly regulated posttranscriptionally involving modulation of RNA stability which is dependent on protein binding to the cognate sequence bases 2179-2195 within the 3' untranslated region of the AT1 receptor RNA. This region contains an AUUUUA hexamer which forms part of a stem-loop structure. To clarify the significance of the AUUUUA hexamer for AT1 receptor mRNA regulation, mutations...
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