Article
Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor.
Trends in endocrinology and metabolism: TEM - 1 Mar 2003
Elton Terry S, Martin Mickey M
Abstract excerpt
Activation of the angiotensin II type 1 (AT(1)) receptor is closely involved in the pathogenesis of cardiovascular diseases; therefore, aberrant regulation of the production of this receptor might play a role in these disorders. Currently, there is strong evidence to suggest that the predominant mechanism regulating the number of AT(1) receptors is the modulation of mRNA stability. Here, we discuss the importance...
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