Article
Angiotensinogen messenger RNA stabilization by angiotensin II.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension - 1 Dec 1996
Klett C P, Printz M P, Bader M, Ganten D, Eggena P
Abstract excerpt
OBJECTIVE: To further characterize the molecular mechanism whereby angiotensin II stabilizes the angiotensinogen messenger (m)RNA through binding studies of the previously isolated polysomal stabilizing protein to partial and mutagenized sequences of the 3' untranslated region of the gene and to explore its importance to rodent genetic hypertension. DESIGN: Analysis of angiotensinogen mRNA mutants for half-life...
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