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Article

Role of the 3′-Untranslated Region of Human Endothelin-1 in Vascular Endothelial Cells

27 Feb 2004

Abstract excerpt

Endothelin-1 (ET-1) is a potent vasoconstrictor peptide expressed in the vascular endothelium. Stringent control over ET-1 expression is achieved through a highly regulated promoter and rapid mRNA turnover. Since little is known about mechanisms governing ET-1 post-transcriptional regulation, and changes in ET-1 mRNA stability are implicated in disease processes, we characterized these pathways using a variety of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 14660616
DOI: 10.1074/jbc.m312190200

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