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Article

Modulating the DNA affinity of Elk-1 with computationally selected mutations.

Journal of molecular biology - 22 Apr 2005

Park Sheldon, Boder Eric T, Saven Jeffery G

Abstract excerpt

In order to regulate gene expression, transcription factors must first bind their target DNA sequences. The affinity of this binding is determined by both the network of interactions at the interface and the entropy change associated with the complex formation. To study the role of structural fluctuation in fine-tuning DNA affinity, we performed molecular dynamics simulations of two highly homologous proteins,...

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Identifiers

PMID: 15808854
DOI: 10.1016/j.jmb.2004.12.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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