Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish.

Thyroid : official journal of the American Thyroid Association - 1 Feb 2021

Han Cho Rong, Wang Hui, Hoffmann Victoria, Zerfas Patricia, Kruhlak Michael, Cheng Sheue-Yann

Abstract excerpt

Background: Mutations of thyroid hormone receptor α1 (TRα1) cause resistance to thyroid hormone (RTHα). Patients exhibit growth retardation, delayed bone development, anemia, and bradycardia. By using mouse models of RTHα, much has been learned about the molecular actions of TRα1 mutants that underlie these abnormalities in adults. Using zebrafish models of RTHα that we have recently created, we aimed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ventricular Function
Share to Bradycardia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Myocardial Contraction

Share to Myocardium

Share to Thyroid Hormone Receptors alpha

Share to Thyroid Hormone Receptors beta

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32762296
DOI: 10.1089/thy.2020.0332
PMCID: PMC7891307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish.PMID 32762296Read ↗

In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish.Semantic proximity Read ↗

Resistance to thyroid hormone induced tachycardia in RTHα syndrome.Semantic proximity Read ↗

Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation.Semantic proximity Read ↗

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone.Semantic proximity Read ↗

Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.Semantic proximity Read ↗

Noonan syndrome-associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish.Semantic proximity Read ↗

Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.Semantic proximity Read ↗

Clinical Consequences of Mutations in Thyroid Hormone Receptor-α1Semantic proximity Read ↗

Thyroid Hormone Receptor α1 Mutants Impair B Lymphocyte Development in a Mouse Model.Semantic proximity Read ↗

Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene.Semantic proximity Read ↗

Resistance to thyroid hormone due to defective thyroid receptor alpha.Semantic proximity Read ↗

Which actin genes are necessary for zebrafish heart development and function?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.