Article

The role of altered calcium handling in the pathogenesis of hypertrophic cardiomyopathy

2014-01-01

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disease carrying a significant risk of sudden cardiac death (SCD) due to arrhythmias. The ACTC (cardiac actin) E99K transgenic (TG) mouse reproduces many aspects of HCM observed in humans. The most striking characteristic is the high probability of SCD at 25-45 days old. The primary effect of this mutation is increased myofilament Ca2+ s...

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Literature Corpus work: 4dd3e3df-bd71-5348-b180-59df2a1bd782
DOI: 10.25560/25000

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