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Clinical Pharmacogenomic MT-RNR1 Screening for Aminoglycoside-Induced Ototoxicity and the Post-Test Counseling Conundrum.

Clinical pharmacology and therapeutics - 1 Aug 2023

Rigobello Robert, Shaw Jay, Ilg Daniel, Zimmerman Rebekah, Edelmann Lisa, Kornreich Ruth, Scott Stuart A, Cody Neal

Abstract excerpt

Aminoglycoside antibiotic exposure can result in ototoxicity and irreversible hearing loss among individuals that harbor the m.1555A>G variant in the mitochondrial 12S rRNA gene, MT-RNR1. Importantly, pre-emptive m.1555A>G screening has been shown to reduce the prevalence of pediatric aminoglycoside-induced ototoxicity; however, professional guidelines to support and guide post-test pharmacogenomic counseling in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37314952
DOI: 10.1002/cpt.2910

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Clinical Pharmacogenomic MT-RNR1 Screening for Aminoglycoside-Induced Ototoxicity and the Post-Test Counseling Conundrum.PMID 37314952Read ↗

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