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Article

Increased frequency of argyrophilic grain disease in Alzheimer disease with 4R tau-specific immunohistochemistry.

Journal of neuropathology and experimental neurology - 1 Mar 2005

Fujino Yasuhiro, Wang Deng-Shun, Thomas Natalie, Espinoza Marisol, Davies Peter, Dickson Dennis W

Abstract excerpt

Argyrophilic grain disease (AGD) is a medial temporal 4R tauopathy with filamentous inclusions in dendrospinal portions of neurons. AGD is often associated with mild Alzheimer-type pathology, but it is difficult to detect AGD in the setting of advanced Alzheimer disease (AD). The frequency of AGD in AD has been difficult to determine because of masking of grains by neurofibrillary lesions. To address this issue,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15804052
DOI: 10.1093/jnen/64.3.209

Genes

MAPT
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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