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Article

Pathology of breast cancer in women with constitutional CHEK2 mutations.

Breast cancer research and treatment - 1 Mar 2005

Huzarski Tomasz, Cybulski Cezary, Domagała Wenancjusz, Gronwald Jacek, Byrski Tomasz, Szwiec Marek, Woyke Stanisław, Narod Steven A, Lubiński Jan

Abstract excerpt

The power of association studies between polymorphic genetic variants and breast cancer may be enhanced if the cancer subjects are subclassified by histologic subgroup. In this study we classified 482 unselected breast cancers from Szczecin, Poland by histology (ductal, lobular, medullary, other). All women were genotyped for three founder mutations in the CHEK2 gene (1100delC, IVS2 + 1G > A and I157T). There was...

Read the complete abstract on PubMed

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Share to Carcinoma, Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15803365
DOI: 10.1007/s10549-004-3778-2

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathology of breast cancer in women with constitutional CHEK2 mutations.PMID 15803365Read ↗

The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

Different CHEK2 germline mutations are associated with distinct immunophenotypic molecular subtypes of breast cancer.Semantic proximity Read ↗

A Comparison between CHEK2*1100delC/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis.Semantic proximity Read ↗

Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

CHEK2-positive breast cancers in young Polish women.Semantic proximity Read ↗

Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.Semantic proximity Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

Association of two mutations in the CHEK2 gene with breast cancer.Semantic proximity Read ↗

Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association ConsortiumSemantic proximity Read ↗

Irrelevance of CHEK2 variants to diagnosis of breast/ovarian cancer predisposition in Polish cohort.Semantic proximity Read ↗

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