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Article

Genotyping of thiopurine methyltransferase using pyrosequencing.

Biological & pharmaceutical bulletin - 1 Apr 2005

Okada Yuko, Nakamura Katsunori, Wada Masanori, Nakamura Tetsuya, Tsukamoto Norifumi, Nojima Yoshihisa, Horiuchi Ryuya, Yamamoto Koujirou

Abstract excerpt

Thiopurine methyltransferase (TPMT) metabolizes thiopurine drugs which are used in the treatment of leukemia and some autoimmune diseases. Previously, 11 mutant alleles of TPMT gene (TPMT*1S, *2, *3A, *3B, *3C, *3D, *4, *5, *6, *7, and *8) have been reported. These mutant alleles may cause life-threatening toxicity in patients exposed to thiopurine drugs, 6-mercaptopurine and azathioprine. We have developed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15802809
DOI: 10.1248/bpb.28.677

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genotyping of thiopurine methyltransferase using pyrosequencing.PMID 15802809Read ↗

Duplex pyrosequencing of the TPMT*3C and TPMT*6 alleles in Korean and Vietnamese populations.Semantic proximity Read ↗

Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene.Semantic proximity Read ↗

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.Semantic proximity Read ↗

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

Clinical utility of thiopurine S-methyltransferase genotyping.Semantic proximity Read ↗

Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.Semantic proximity Read ↗

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.Semantic proximity Read ↗

Validation of new allele-specific real-time PCR system for thiopurine methyltransferase genotyping in Korean population.Semantic proximity Read ↗

Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.Semantic proximity Read ↗

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.Semantic proximity Read ↗

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.Semantic proximity Read ↗

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