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Article

Clinical utility of thiopurine S-methyltransferase genotyping.

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2004

Corominas Hèctor, Baiget Montserrat

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that plays a major role in the metabolism of thiopurine drugs such as mercaptopurine and azathioprine. The interindividual differences in response to thiopurine administration is in part due to the presence of genetic polymorphisms in the gene that regulates TPMT activity. TPMT genotype correlates well with the in vivo enzyme activity within...

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Source

Identifiers

PMID: 14987117
DOI: 10.2165/00129785-200404010-00001

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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