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Mitochondrial theory of aging matures--roles of mtDNA mutation and oxidative stress in human aging.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed - 1 May 2001

Wei Y H, Ma Y S, Lee H C, Lee C F, Lu C Y

Abstract excerpt

Mitochondrial theory of aging, a variant of free radical theory of aging, proposes that accumulation of damage to mitochondria and mitochondrial DNA (mtDNA) leads to aging of humans and animals. It has been supported by the observation that mitochondrial function declines and mtDNA mutation increases in tissue cells in an age-dependent manner. Age-related impairment in the respiratory enzymes not only decreases...

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PMID: 11499335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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