Article
Mitochondrial DNA alterations and reduced mitochondrial function in aging.
Mechanisms of ageing and development - 1 Jan 2000
Hebert Sadie L, Lanza Ian R, Nair K Sreekumaran
Abstract excerpt
Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the...
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