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MtDNA mutations, functional decline and turnover of mitochondria in aging.

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Pang Cheng-Yoong, Ma Yi-Shing, Wei Yau-Uei

Abstract excerpt

Aging is a complex biological process that involves gradual function deterioration in various tissues and organs of an individual. Mitochondrial function decline can lead to cellular overproduction of reactive oxygen species (ROS) and increase in oxidative damage to biological molecules in the aging process. We have hypothesized that increased production of ROS by the mitochondria in affected tissues in patients...

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Aging
DNA, Mitochondrial
Gene Expression Regulation, Developmental
Mitochondria
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Phosphorylation

Reactive Oxygen Species

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PMID: 18508463
DOI: 10.2741/2957

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