Article
Identification of a novel pharmacophore for peptide toxins interacting with K+ channels.
The Journal of biological chemistry - 3 Jun 2005
Verdier Laurent, Al-Sabi Ahmed, Rivier Jean E F, Olivera Baldomero M, Terlau Heinrich, Carlomagno Teresa
Abstract excerpt
KappaM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to many other peptides targeting K+ channels, kappaM-RIIIK does not possess a functional dyad. In this study we combine thermodynamic mutant cycle analysis and docking calculations to derive the binding mode of kappaM-conotoxin RIIIK to the TSha1 channel. The final model reveals a...
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