Article
Molecular simulation of the interaction of kappa-conotoxin-PVIIA with the Shaker potassium channel pore.
European biophysics journal : EBJ - 1 Dec 2001
Moran O
Abstract excerpt
Molecular simulation techniques were appplied to predict the interaction of the voltage-dependent Shaker potassium channel with the channel-blocking toxin kappa-conotoxin-PVIIA (PVIIA). A structural thee-dimensional model of the extracellular vestibule of the potassium channel was constructed based on structural homologies with the bacterial potassium channel Kcsa, whose structure has been solved by X-ray...
Topics
- Algorithms
- Amino Acid Sequence
- Animals
- Conotoxins
- Crystallography, X-Ray
- Drosophila Proteins
- Drosophila melanogaster
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Potassium Channels
- Protein Binding
- Shaker Superfamily of Potassium Channels
- Streptomyces